A case of erythroderma caused by apalutamide
LIU Yan
LI Xiaohong
BAI Feiying
HE Yixuan
Abstract：We report a case of erythroderma induced by apalutamide in a patient with prostate cancer.A 73-year-old man presented with pruritic erythema and scaling on the trunk and limbs for over two months.The patient was diagnosed with prostate cancer six months ago.After regularly taking apalutamide tablets,traditional Chinese medicine,and other medications for two months,he developed red rashes accompanied by itching,which later merged into red plaques,with the lower limbs being most affected.Dermatological examination revealed diffuse erythema and scaling on the trunk and limbs,covering more than 90％of the body surface area.Laboratory tests indica-ted an elevated absolute eosinophil count.During the first hospitalization,apalutamide was not discontinued,but traditional Chinese medicine was stopped.The patient was treated with cortico-steroids and antihistamines,leading to improvement.However,the skin lesions worsened after ta-pering the corticosteroids.During the second hospitalization,histopathological examination showed liquefaction degeneration of basal cells and dermal lymphocytic infiltration with a small number of eosinophils.The patient's erythroderma was considered to be induced by apalutamide.Apalu-tamide was discontinued and corticosteroid therapy was continued,resulting in sustained improve-ment of the skin lesions.The patient is still under follow-up.
Keywords：apalutamideerythrodermaprostate cancer
Publication Date：2025-07-28
Online Publishing Date：2025-08-20(First online date of this platform, not the publication date of the document)
Pages：5( 534-538 )