Association between infusion timing of immune checkpoint inhibitors and outcomes:a ret-rospective analysis in Chinese melanoma patients
ZHANG Qiong
YU Junshan
WU Junwan
CHEN Ziluan
ZHANG Rongcheng
DING Qiuyue
CHEN Linbin
LI Jingjing
WEN Xizhi
ZHANG Xiaoshi
DING Ya
LI Dandan
Abstract：Objective To determine the relationship between specific timing pattern of im-mune checkpoint inhibitor infusion and the prognosis of Chinese melanoma patients.Methods Clinical data were collected from 126 melanoma patients who received immune checkpoint inhibi-tors in Sun Yat-sen University Cancer Center between April 2015 and March 2024.Patients who received ≥ 20％ of PD-1 antibody infusions after 16:30 were assigned to the afternoon group,while those who received＜20％ of infusions after 16:30 were assigned to the morning group.Sur-vival outcomes between the two groups were compared using the log-rank test to determine statisti-cal significance.Results Among 61 patients who received adjuvant PD-1 antibody therapy,the median recurrence-free survival(RFS)was 9.10 months in the morning group and 19.57 months in the afternoon group,with no significant difference(P=0.546).The median overall survival(OS)in the afternoon group was not inferior to that in the morning group(NR vs.47.77 months,P=0.950,HR=0.98).Among 65 patients who received palliative PD-1 antibody therapy,the median progression-free survival(PFS)was 3.57 months in the morning group and 5.60 months in the afternoon group,with no statistically significant difference(P=0.260).Compared to the morning group,the afternoon group showed a significantly longer median overall survival(OS)(22.70 vs.14.40 months,P=0.047,HR=0.53).However,the analysis of prognostic factors revealed that receiving ≥20％ of PD-1 antibody infusions in the afternoon was not an independent risk factor for survival in this cohort.Conclusions The daily infusion timing of immune check-point inhibitors may not significantly influence survival in Chinese melanoma patients.However,multicenter prospective studies are still needed to further validate the potential chronotherapeutic effects in immunotherapy.
Keywords：melanomachronotherapycircadian rhythmChinese patientsimmune checkpoint inhibitorsdaily infusion time
Publication Date：2025-07-28
Online Publishing Date：2025-08-20(First online date of this platform, not the publication date of the document)
Pages：9( 476-484 )