Research progress on the role of prostaglandins in atopic dermatitis
WANG Mingxin
DONG Liping
XIAO Fengli
Abstract：Atopic dermatitis(AD)is a chronic inflammatory skin disease mediated by genetic,immune,and environmental factors.Prostaglandins(PGs),as critical lipid mediators,exert com-plex regulatory roles in AD.This review systematically summarizes the dual regulatory roles and molecular mechanisms of PGD2,PGE2,PGI2,and thromboxane A2 in AD.PGD2 bidirectionally regulates barrier repair and type 2 inflammatory responses via DP1/CRTH2 receptors;PGE2 sup-presses aberrant inflammation and immune activation while simultaneously inducing pruritus and disrupting epidermal barrier;PGI2 maintains immune homeostasis through IP receptors.TXA2 promotes pruritus and inflammation through TP receptor and is associated with an increased risk of early-onset AD.Although drugs targeting PG pathways have shown potential in animal models,their effectiveness in clinical trials remains limited.
Keywords：atopic dermatitisprostaglandinprostaglandin D2prostaglandin E2pros-taglandin I2thromboxane A2
Publication Date：2025-06-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 436-441 )