Successful treatment of a case of dupilumab-induced psoriasis and alopecia areata with to-facitinib
SUN Feifei
QIU Xiaoye
PAN Futang
Abstract：We report a case of dupilumab-induced alopecia areata and psoriasis successfully treated with a JAK inhibitor.A 33-year-old woman presented with recurrent erythema and itching for over 10 years.Dermatological examination showed dry skin on the trunk and limbs,with wide-spread erythemas and papules,some merging into patches,particularly in the skin folds.Labora-tory tests showed increased eosinophils(20.4％)and immunoglobulin IgE(14 718 g/L).She was diagnosed with atopic dermatitis.Due to poor response to conventional treatments(difficulty tapering systemic glucocorticoids),dupilumab was administered(600 mg initially,followed by 300 mg every two weeks).While atopic dermatitis was improved,psoriasis-like lesions appeared on the abdomen and thighs after one month,and alopecia areata developed on the scalp after two months.To maintain treatment and control adverse effects,JAK inhibitor,tofacitinib(5 mg twice daily),was introduced.Psoriatic lesions disappeared and new hair could be seen on the eyebrows and the scalp,and the hair returned to normal after three months of treatment with tofacitinib,with no recurrence of atopic dermatitis observed during a one-year follow-up.
Keywords：atopic dermatitisdupilumabpsoriasisalopecia areataJAK inhibitortofacitinib
Publication Date：2025-06-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 427-431 )