Clinical observation on the efficacy of 35％glycolic acid combined with recombinant human interferon alpha-2 β cream for treating facial flat warts
HOU Jingmei
YANG Yanping
PU Xiaoxia
LI Yunfeng
SONG Hongbin
YANG Rui
Abstract：Objective To evaluate the efficacy of 35％glycolic acid combined with recombi-nant human interferon α-2β ointment for treating facial flat warts.Methods A total of 71 patients with flat warts who visited the Dermatology Department of Ningxia Hui Autonomous Region People's Hospital from January 2023 to December 2023 were randomized into a treatment group(36 cases)and a control group(35 cases)using a random number table.The treatment group received 35％glycolic acid therapy once every two weeks and topical recombinant human interferon α-2 β oint-ment(four times daily),while the control group received only the interferon ointment(four times daily).Treatment was discontinued upon complete lesion resolution,with a maximum treatment duration of 3 months.After the treatment,the regression of skin lesions,adverse reactions,and recurrence rates were compared between the two groups.Results Thirty-five patients completed the study in each group.The treatment group achieved a total effective rate of 77.14％(27/35,including 2 cured and 25 markedly improved cases),which was significantly higher than that of the control group,42.86％(15/35,1 cured and 14 improved)(x2=8.57,P=0.003).After a 3-month follow-up,the recurrence rate in the treatment group(11.43％)was slightly lower than that in the control group(20.00％),but the difference was not statistically significant(P=0.342).No severe adverse reactions occurred in either group.Conclusion The combination of 35％glycolic acid and recombinant human interferon α-2 β ointment is an effective treatment for facial flat warts,with few adverse reactions.
Keywords：facial flat warts35fruit acidrecombinant human interferon alpha-2βcream
Publication Date：2025-05-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 335-338 )