Analysis of the efficacy of tranexamic acid combined with Q-switched laser and chemical peeling for the treatment of stable melasma
ZHANG Qinghua
HUANG Weiquan
ZHANG Xian
SI Weizhen
ZHONG Jing
Abstract：Objective To analyze the efficacy of tranexamic acid(TXA)combined with Q-switched laser and chemical peeling(α hydroxyl acid)for the treatment of stable melasma.Meth-ods A total of 93 patients with stable melasma were recruited and randomly divided into group A(oral TXA+chemical peels)with 31 cases,group B(oral TXA+Q-switched laser)with 32 ca-ses,and group C(oral TXA+Q-switched laser+chemical peeling)with 30 cases.After the treatment,the efficacy was evaluated,and adverse reactions were observed.Results After 12-week treatment,the total effective rate in group C(80.00％)was significantly higher than that in group A(29.03％)and group B(56.25％)(both P＜0.05 vs.group C).Skin lesion color,lesion area,and mMASI scores were lower in group C compared to groups A and B(both P＜0.05 vs.group C).No severe adverse reactions occurred in any patients during the treatment.Conclusion The combination of tranexamic acid,Q-switched laser,and chemical peeling is an effective treatment for stable melasma,with few adverse reactions.
Keywords：melasmaQ-switch laserchemical peelingtranexamic acid
Publication Date：2025-05-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 329-334 )