Research progress on the interactions between Treponema pallidum adhesion proteins and host cells
HUANG Jialin
ZHENG Judun
Abstract：Treponema pallidum(Tp)has an outer membrane that encircles the periplasmic space,the peptidoglycan,cytoplasmic membrane,and protoplasmic components.The low abun-dance of lipopolysaccharides and transmembrane proteins enable it to conceal itself and to exert ro-bust capabilities for tissue invasion and immune escape.Adhesion-mediated colonization plays a significant role in the pathogenesis of syphilis caused by Tp.In vitro studies have shown that Tp can adhere to cells of humans and other mammals,with a preference for interacting with specific molecules on certain cell surfaces,thereby influencing the invasion,pathogenicity and immune es-cape of Tp.This review summarizes how adhesion proteins of Tp interact with various host cells to trigger invasion and infection,and overviews their role in syphilis pathogenesis,aiming to offer significant insights for research into etiology,vaccine development,and the discovery of novel therapeutic agents for syphilis.
Keywords：Treponema pallidumadhesin proteinhost cells
Publication Date：2025-03-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 215-221 )