Clinical study on the efficacy of tranexamic acid combined with narrowband intense pulsed light for the treatment of melasma
XUE Chengyi
GUO Kaizhong
ZHANG Guocheng
CHEN Jun
Abstract：Objective To investigate the efficacy and patients'satisfaction of combing narrow-band intense pulsed light(DPL)with tranexamic acid for the treatment of facial melasma.Meth-ods Ninety melasma patients treated at Gaoyou People's Hospital between November 2022 and August 2024 were randomly divided into three groups(30 patients per group).The medication group received oral tranexamic acid tablets(0.25 g twice daily for 6 months),while the DPL group underwent DPL treatment once per month for 4 sessions.The combination group received both interventions following the same protocols as the other two groups.The melasma area and se-verity index(MASI)scores were compared before and after the treatment.The efficacy and pa-tients'satisfaction were evaluated after the treatment.Adverse reactions and recurrence rates were also monitored.Results After the treatment,the combination group achieved a greater reduction in MASI scores than the other two groups(62.20±19.14％vs.48.10±22.18％in the DPL group and 45.32±20.74％in the medication group,P＜0.05).Moreover,both total effective rate and patients'satisfaction scores were higher in the combination group than the other groups(80.00％vs.53.33％in the DPL group and 50.00％in medication group,P＜0.05).No sig-nificant adverse reactions were observed across groups.At six-month follow-up,no recurrence was observed in the combination group,while 2 cases were reported in the DPL group and 1 case in the medication group.Conclusion The combination of DPL and tranexamic acid represents a safe and effective approach for the management of melasma.
Keywords：melasmatranexamic acidnarrowband intense pulsed light
Publication Date：2025-03-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 190-195 )