Research advances in the pathomechanisms and treatment of sensitive skin
NOH Youngji
CAO Ting
YE Chengbin
ZOU Ying
Abstract：Sensitive skin(SS)is a complex condition with multifactorial pathogenesis,inclu-ding impairment of the skin barrier function,dysbiosis of the skin microbiome,abnormal cutane-ous nervous and vascular response,and dysregulated immune and inflammatory responses.Current treatment strategies primarily focus on restoring the skin barrier using moisturizers containing ce-ramides,hyaluronic acid,and other ingredients to reduce transepidermal water loss and enhance barrier function.Moreover,utilities of TRPV1/TRPV4 antagonists and anti-inflammatory agents can reduce hypersensitivity of sensory nerves,resulting in decrease in neural activity and allevia-tion of discomfort.In addition,probiotics can modulate microbiota imbalance,leading to ameliora-tion of cutaneous inflammation.Thus,sensitive skin requires comprehensive treatment that can ad-dress multiple pathways simultaneously.This review aims to summarize recent advances in the pathogenesis of SS,and analyze the interactions among various pathogenic contributors,providing a scientific basis for future research and clinical interventions.
Keywords：sensitive skinpathogenesisskin barrierskin microbiometreatment
Publication Date：2025-02-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：9( 140-148 )