The relationship between the skin microecology and the skin barrier
LIN Tianyi
CHEN Jiaoquan
OU Shanshan
WU Weihong
ZOU Hui
CHEN Ziyan
PENG Liqian
CHEN Quan
LI Huaping
ZHU Huilan
Abstract：With the development of metagenomics sequencing and spatial transcriptomics,the door to the"microscopic world"of the skin surface has gradually been opened,and the"inhabit-ants"on the"habitat"of the skin have gradually become well-known.These microbial inhabitants contribute greatly to the homeostasis of the skin microenvironment by communicating with the host cells and maintaining the structural integrity and function of the skin barrier.The skin barrier does not only provide a living environment for epidermal microorganisms,but also regulates the compo-sition of the skin microbial community in terms of physics,chemistry and immunity.Therefore,disruption of the skin barrier or imbalance of the skin microbiome can profoundly impact the be-havior of host cells.The colonization of pathogenic bacteria and the loss of microbial diversity will activate the molecular signaling pathways that mediate the immune inflammatory response,resul-ting in the production and aggravation of many skin diseases,such as atopic dermatitis,acne,psoriasis,solar diseases,etc.Based on the current research status in skin microbiota,this article discusses the process of the interaction between skin microbiota and skin barrier,as well as the re-lationship between skin barrier damage and skin microbiota imbalance in the course of diseases.
Keywords：skin barriermicroorganismskin microbiotaskin diseases
Publication Date：2025-02-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 132-139 )