Role of non-coding RNAs in skin photoaging
HE Zezhi
CHEN Jiazhen
WU Hui
SHEN Haojia
LI Runxiang
ZHU Huilan
Abstract：Skin photoaging,a phenomenon of premature skin aging due to prolonged exposure to ultraviolet(UV)radiation,manifests as wrinkles,loss of skin elasticity,pigmentation disor-ders,and age spots.Non-coding RNAs(ncRNAs),including microRNAs(miRNAs),long non-coding RNAs(lncRNAs),and circular RNAs(circRNAs),play a crucial role in regulating gene expression and the development of skin photoaging.This review summarizes the molecular mecha-nisms of specific ncRNAs(such as miR-34a,miR-134,miR-1246,lncRNA H19-miR-296-5p-IGF2,lncRNA PVT1-miR-551b-3p-AQP3,lncRNAMeg3-miR-93-5p-epiregulin,circ-COL3A1-859267 and circ-0011129)in skin photoaging.Additionally,the review discusses the potential application of ncRNA-based therapies in photoaging,as well as the current challenges and future research directions.
Keywords：skin photoagingnon-coding RNAmiRNAlncRNAcircRNAinflam-matory responseoxidative stressextracellular matrix remodeling
Publication Date：2024-11-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 783-788 )