Advances in the pathogenesis and treatment of Nagashima-type palmoplantar keratosis
LI Kezhen
LU Antong
ZHONG Weilong
YU Bo
Abstract：Nagashima-type palmoplantar keratosis(NPPK)is a relatively common autosomal recessive dermatosis characterized by well-defined diffuse erythema and non-destructive hyperkera-tosis on the palmoplantar areas,with swelling and whitening when exposed to water.The patho-genesis of NPPK can be attributable to altered structure and function of SERPINB7,environmental factors,barrier dysfunction and inflammatory response.There is no specific and standardized ther-apy for this disorder.Topical treatment is primary therapy although systemic drugs or surgery can be used for severe cases.Gentamicin,a targeted therapy for the disease,has shown some poten-tial,but more clinical studies are still needed to verify its efficacy and safety.The aim of this re-view is to summarize the causative gene,pathogenesis and therapeutic strategies of NPPK.
Keywords：nagashima-type palmoplantar keratosisSERPINB7genetic mutationpath-ogenesisgentamicin
Publication Date：2024-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 721-726,封3 )