Manifestations and pathogenesis of the sebaceous gland aging
ZHENG Siqi
CHEN Shuqiong
ZHONG Meizhen
ZHENG Yue
HUANG Xiaowen
Abstract：Aging in the sebaceous glands typically begins on the sun-exposed areas,character-ized by sebaceous gland hyperplasia and lipid dysbiosis.These changes result in dry and dull skin,alterations in the microbiota,pigmentation,and various skin diseases.Both intrinsic and ex-trinsic factors contribute to this process,causing dilation of sebaceous ducts,reducing lipid secre-tion,promoting gland proliferation,and inducing inflammation.Key downstream mechanisms driv-ing sebaceous gland aging include reactive oxygen species(ROS),autophagy,the Wnt signaling pathway,and mitochondrial dysfunction.Interventions such as antioxidants,probiotics,photother-apy,and exosomes can delay the sebaceous gland aging.This article will discuss the manifesta-tions of the sebaceous gland aging,elucidate its underlying mechanisms,review current research progress,and explore potential countermeasures.
Keywords：sebaceous gland agingsebaceous glandmitochondrial diseasesautoph-agymicrobiotaexosomes
Publication Date：2024-09-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：9( 634-642 )