Research progress on the treatment of bullous pemphigoid with Dupilumab
LUO Xiaojia
JIANG Fuqiong
ZHANG Yaozhong
GAO Jian
Abstract：In recent years,there have been many reports on the use of Dupilumab in the treat-ment of bullous pemphigoid.Dupilumab specifically binds to the subunit alpha of interleukin 4 re-ceptor(IL-4Rα),blocking the signal transduction of interleukin(IL)-4 and IL-13,inhibiting the proliferation of B cells,reducing the recruitment of eosinophils,and suppressing the function of Th2-related chemotactic factors,thereby improving skin lesions and itching of patients.This arti-cle reviews the potential mechanisms,clinical efficacy,and adverse reactions of Dupilumab in the treatment of bullous pemphigoid.
Keywords：bullous pemphigoidtreatmentDupilumab
Publication Date：2024-08-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 560-566 )