Research progress on innate lymphoid cells 3 in skin wound healing
ZHANG Wei
HANG Qianru
XU Tengjiao
WENG Yuge
DING Yan
Abstract：The skin wound healing is a complex physiological process involving coagulation,inflammation,proliferation,and remodeling.Innate immune cells play a crucial role in regulating signaling factors during skin wound healing.Due to their unique tissue distribution and origin,in-nate lymphoid cells 3(ILC3),a member of innate immune cells,have the potential to regulate the wound healing process.They can secrete multiple cytokines,such as IL-17,IL-22,and GM-CSF,to maintain skin homeostasis,promote keratinocyte proliferation and epithelial cell migra-tion,and participate in wound tissue reconstruction.The function of ILC3 is regulated by various signaling pathways,including RA-RAR,FFAR2,vitamin D receptor,DR3,and AhR,making them potential integrators of microenvironment around the wound.Numerous studies suggest the importance of ILC3 in skin wound healing,making them a potential therapeutic target in wound healing.This article comprehensively reviews the origin,tissue distribution,function,and signa-ling receptors of ILC3 and summarizes recent advances in the study of ILC3 in skin wound heal-ing.
Keywords：skin wound healinginnate lymphocytes cell 3innate immunityinterleu-kins
Publication Date：2024-03-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 203-208 )