The role of leptin in psoriasis
CHEN Lin
XIONG Hui
GUO Qing
Abstract：Psoriasis,a systemic immune-inflammatory disease,is often associated with meta-bolic syndromes such as obesity.As the most classical pro-inflammatory adipokine,leptin has re-ceived persistent attention in psoriasis.Currently,it is generally believed that leptin promotes the development of psoriasis.This article delves into the intricate relationship between leptin and the development of psoriasis,along with its associated metabolic complications.Additionally,the po-tential mechanisms by which leptin operates in the pathological processes of psoriasis,such as im-mune inflammatory activation,epidermal keratinocyte proliferation,differentiation and secretion of proinflammatory factors,and proliferation and dilatation of dermal papillary capillaries,are ex-plored.
Keywords：psoriasisleptinimmune cellskeratinocytescapillaries
Publication Date：2024-03-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 198-202 )