Advances in the study of the association between IL-17 and acne
DUAN Yixue
WEN Ju
QIN Si
HUANG Wenbin
LI Mujin
Abstract：Acne is a chronic inflammatory disease involving the sebaceous unit of hair follicles,with a complex pathogenesis.Currently,it is believed that the pathogenesis of acne is related to androgen levels,excessive sebum secretion,hyperkeratosis of hair follicles,C.acnes and others.In recent years,studies have revealed the pathogenic role of a variety of inflammatory factors in ac-ne,among which IL-17 is highly expressed in the epidermis and serum of acne patients,and its levels are positively correlated with the severity of acne,becoming a biomarker for early diagnosis of acne.A large amount of evidence indicates the involvement of IL-17 in the pathogenesis of ac-ne,possibly playing a dominant role.IL-17 is involved in the inflammatory cascade of various ac-ne,thereby changing severity of inflammation.But the specific mechanisms are not clear.This ar-ticle reviews the research progress of the correlation between IL-17 and acne,and discusses the anti-inflammatory and therapeutic effects of anti-IL-7 on acne,in order to determine the pathogen-ic role of IL-17 in acne.
Keywords：acneIL-17IL-17AC.acnes
Publication Date：2023-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 534-538 )