Efficacy of compound middle-layer acid combined with 30％supramolecular salicylic acid for melasma
SUN Yu
YE Congxiu
FU Jiaojiao
CHEN Xinling
ZHOU Feng
JIANG Yuhan
LAI Wei
ZHENG Yue
Abstract：Objective To evaluate the therapeutic efficacy of a combination of compound mid-dle-layer acid and 30％supramolecular salicylic acid for melasma.Methods Five female pa-tients with melasma who were admitted to our hospital from May 2022 to December 2022 were en-rolled in this study.A self-parallel controlled study was carried out.The patients'treated side was treated with compound middle-layer acid while the control side was treated with 30％supramolecu-lar salicylic acid at weeks 0 and 4.On week 8,the treated side and control side were treated with 30％supramolecular salicylic acid and compound middle-layer acid,respectively.We compared the area score of facial lesions,skin color,sebum,water content and the severity of melasma-re-lated psychological stress between the two sides.Results The combination therapy significantly decreased the area scores on the forehead,cheek and chin(P＜0.05).In contrast,only the area scores on the forehead were decreased on the control side.Although the color scores were de-creased on the forehead,cheek and chin of both sides,significant decrease was observed on the treated side(P＜0.05 vs.the control side).Similarly,both treatments increased sebum con-tent,with a prominent increase on the treated side(P＜0.05 vs.the control side).The changes in water content did not differ significantly between these two treatments(P＞0.10).Moreover,the combination therapy decreased both SAS(from 21.62±5.99 to 20.86±6.44,P＜0.05)and SDS scores(from 25.05±4.21 to 23.33±5.12,P＜0.05).Conclusions The combina-tion therapy of compound middle-layer acid and 30％supramolecular salicylic acid can significant-ly improve the facial skin lesions and psychological state of patients with melasma.Better results can be achieved by using compound middle-layer acid first,followed by 30％supramolecular sali-cylic acid.
Keywords：melasmacompound middle-layer acidsalicylic acid
Publication Date：2023-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 502-508 )