The Influence of Narrow-band Ultraviolet B on Th22 Cells and Related Cytokines Expres-sion in Patients with Psoriasis Vulgaris
GUO Xiao-lan
DENG Lie-hua
YANG Wen-biao
LI Xiu-juan
Abstract：Objective:To observe the therapeutic effect and the influence on Th 22 cells and re-lated cytokines in peripheral blood of psoriasis vulgaris that were treated with narrow -band ultravio-let B ( NB-UVB) , and to analyze NB-UVB's mechanism of action .Methods:Forty cases of psoria-sis vulgaris were treated with 20 times NB-UVB radiation .The therapeutic effect was evaluated u-sing Psoriasis Area and Severity Index ( PASI ) scores.Peripheral blood was obtained from nor-mal, healthy controls and patients with psoriasis vulgaris before and after NB-UVB radiation treat-ment.Three-color flow cytometry was carried out to detect the quantity of Th 22 cells.ELISA was used to detect levels of serum IL-6 and IL-22.Results:The mean PASI scores of patients de-creased significantly after treatment with NB-UVB radiation ( P <0.01 ) .Levels of Th22 , IL-6 and IL-22 in patients with psoriasis vulgaris before treatment were significantly higher than those of healthy controls (P<0.01).After treatment with NB-UVB,levels of Th22 [(1.19 ±0.31)%], IL-6 [ ( 15.27 ±1.66 ) pg/mL ) ] and IL-22 [ ( 38.52 ±3.31 ) pg/mL ] decreased significantly ( P<0.01 ) in patients with psoriasis vulgaris , and were positively correlated with PASI ( P <0.05).Conclusion:NB-UVB may play a role in the treatment of psoriasis vulgaris by affecting Th22 cells and related cytokines .
Keywords：PsoriasisNarrow-band ultravioletTh22 cellsInterleukin-6Interleu-kin-22
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 168-171 )