Study on the Correlation between Angiopoietin-2 and VEGF in Patients with Psoriasis Vul-garis
LUO Quan
ZHAO Tian
ZHANG Fang
LI Wei
LIN Ling
PAN Ning
ZHANG Xi-bao
Abstract：Objective:To investigate the level of angiopoietin-2 and VEGF of psoriatic lesions and serum in patients with psoriasis vulgaris, and to explore the significance in the pathogenesis of psoriasis.Methods:The expression of angiopoietin-2 and VEGF in skin lesions of 30 patients with psoriasis vulgaris and 30 normal controls were detected by immunohistochemistry technique.Lev-els of angiopoietin-2 and VEGF in sera were measured by double antibody sandwich enzyme-linked immunosorbent assay ( ELISA) in patients with psoriasis vulgaris and normal controls.Results:The expression of angiopoietin-2 and VEGF in psoriatic lesions were remarkable higher than those in normal controls(χ2 =9.64,20.12, both P<0.01).Serum level of angiopoietin-2 and VEGF were significantly higher in patients with psoriasis than those in normal controls ( t=3.49,4.76, both P<0.05 ) .The level of angiopoietin-2 and VEGF in serum were associated with PASI scores ( r=0.59 ,0.77 ,both P<0.01 ) .Conclusion:Angiopoietin-2 and VEGF play an important role in the angiogenesis in psoriasis.Both may play a role in promoting mutual by synergistic effect.
Keywords：PsoriasisAngiopoietinVEGF
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 357-360 )