The Relationship between Plasma Wnt5a and Sfrp5 Levels and Obesity in Psoriasis Vulgaris
JI Su-yun
ZANG Zhi-jun
MA Han
YUAN Li-yan
QI Shi-ling
WANG Yu
BAI Shun
GU Mei
YANG Bin
Abstract：Objective:To explore the relationship between plasma Wnt5a and Sfrp5 levels and obese of patients with psoriasis vulgaris.Methods:20 non-obese controls, 20 obese controls, 20 non-obese psoriasis patients and 20 obese psoriasis patients were enrolled in this study.Plasma Wnt5a and Sfrp5 concentrations were measured through enzyme-linked immunosorbent assay ( ELISA) and compared.Results:Wnt5a was significantly higher in non-obese patients with psori-asis ( 0.105 ±0.049 ng/mL ) and obese psoriasis patients ( 0.320 ±0.155 ng/mL ) compared with non-obese healthy controls (0.082 ±0.054 ng/mL) (both P<0.01).Sfrp5 was significant-ly lower in obese healthy men (55.85 ±13.65 ng/mL, P=0.001) and non-obese patients with psoriasis vulgaris ( 58.09 ±16.78 ng/mL, P=0.01 ) compared with non-obese healthy controls (75.11 ±19.72 ng/mL).Conclusion:Wnt5a and Sfrp5 may play a role in psoriasis vulgaris and obesity, and they may be an important media of psoriasis and metabolic syndrome.
Keywords：Wnt5aSfrp5PsoriasisObesity
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 281-284 )