Expression and Clinical Significance of miR-146a in Peripheral Blood Mononuclear Cell of Patients with Psoriasis Valguris
LUO Quan
LIU Wei-yu
ZHAO Tian
ZHANG Fang
LI Wei
LIN Ling
ZHANG Xi-bao
Abstract：Objective:To detect the expression of miR-146a in peripheral blood mononuclear cell ( PBMC) of patients with psoriasis valguris and investigate the correlation between miR-146a and pathogenicity of psoriasis valguris.Methods:The level of miR-146a in the PBMC from 30 psoriasis valguris patients was measured by quantitive revere transcription polymerase chain reac-tion ( RT-PCR) , and its relationship with disease activity index of psoriasis vulgaes patient was in-vestigated.Results:The copies of miR-146a in PBMC of psoriasis vagulars patients was signifi-cantly higher than that in healthy control group ( P<0.05 ) , and there was significant difference between the active stage and the resting stage of psoriasis vulgaris ( P<0.05 ) .The expression of miR-146a has a positive corelation with PASI scores(r=0.62,P<0.05).Conclusion:Elevated miR-146a levels in peripheral blood mononuclear cell ( PBMC) of patients with psoriasis valguris are associated with a high stage of psoriasis vulgaris which indicate that miR-146a probably play an important role in the pathogenesis of psoriasis vulgaris.
Keywords：PsoriasismiR-146aPeripheral blood mononuclear cell
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 278-280 )