Clinical Evaluation of (1, 3)-β-D-glucan in the Diagnosis of Invasive Fungal Infection
CAI Wen-ying
LU Chang-ming
XI Li-yan
Abstract：Objective:To evaluate the clinical value of(1, 3)-β-D-glucan (BDG) on the diag-nosis of invasive fungal infection.Methods:The suspected invasive fungal infection patients from Sun Yet-sen memorial hospital were enrolled in this study.The blood samples were taken from each patient and tested by determination of (1, 3)-β-D-glucan and culture.The sensitivity, spe-cificity, positive predictive value and negative predictive value were compared between these two methods.Results:171 patients were identified as positive by the detection of plasma BDG, with the positive rate of 50.89%( 171/336 ) .141 samples were identified as positive by fungal cul-tures, with the positive rate of 41.96%(141/336) .The concentration of plasma BDG in the inva-sive fungal infection group with positive fungal culture was (131.18 ±102.91) pg/mL, w hile the concentration of plasma BDG in invasive fungal infection group with negative fungal culture was (45.06 ±33.64 ) pg/mL.There were statistically significant differences in the concentration of plasma BDG between the two groups(t=9.57, P<0.01).Based on the results of the fungal cul-tures, the sensitivity, specificity, and positive and negative predictive values for BG were 54.61%(77/141), 51.79%(101/195), 45.03%(71/171) and 61.21%(101/165), respectively.The genus of Candida is still the predominant pathogens of invasive fungal infection.Conclusions:The determination of plasma (1, 3)-β-D-glucan could be used as an fast tool for invasive fungal infec-tion diagnosis, but the results need to be confirmed by culture.The combination of both methods could be used for routine diagnosis of invasive fungal infection in clinic.
Keywords：Invasivefungalinfection(13)-β-D-glucanFungalcultureDiagnosis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 175-178 )