The Expression and Clinical Significance of IL-17/IL-23 Inflammatory Axis in Chronic Spontaneous Urticaria
ZHANG Jie
DOU Xia
SHAO Yong
YU Bo
HUANG Hai-yan
LIU Li-ming
ZHONG Wei-long
ZHOU Jing
ZHENG Jie-cheng
Abstract：Objective:To investigate the expression and clinical significance of IL-17/IL-23 in-flammatory axis in chronic spontaneous urticaria ( CSU) .Methods:Serum level of IL-17、IL-23 were detected in 158 CSU patients and 121 healthy controls by ELISA.The CSU patients were di-vided into two groups with autologous serum skin test(ASST), and the levels of IL-17、IL-23 of two groups were compared.Results:The levels of IL-17 and IL-23 in CSU patients were signifi-cantly higher than that of controls(t=13.02, 3.87, P<0.01).And the levels of IL-17 and IL-23 in ASST positive CSU patients were higher than in ASST negative CSU patients ( t =8.36, 4.96 , P <0.01 ) .Conclusion:The IL-17/IL-23 inflammatory axis plays an important role in CSU, and it can effect autoimmunity level.
Keywords：Chronic spontaneous urticariaIL-17IL-23
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 102-104 )