A study of Related Viruses in 147 Dermatitis Medicamentosa Patients

YIN Yong-xing; ZENG Qing-hai; LIAO Zhi-ling; ZHANG Gui-ying; XIAO Rong

doi:10.3969/j.issn.1674-8468.2015.02.002

Abstract：Objective:To explore the role of human herpes virus ( HHV-6, HHV-7, EBV, CMV) and parvovirus ( PVB19 ) infection in the Etiology of drug eruption.Methods:The sera from patients with dermatitis medicamentosa ( n=147 ) and health volunteers ( n=33 ) were col-lected.Antigen of HHV-6, HHV-7, EBV, CMV and PVB19 were detected by ELISA.The differ-ences between patients with DIHS , severe drug eruption , non-severe drug eruption and healthy people were analyzed.Results:The virus infection rate of DIHS group, severe drug eruption group, non-severe drug eruption group and healthy controls was 71.4%, 45.1%, 21.3%, 24.2%, respectively, of which HHV-6-positive rates were 33.3%, 21.6%, 5.3%, 0;HHV-7-positive rates were 33.3%, 17.6%, 8.3%, 6.1%; EBV-positive rates were 42.9%, 27.5%, 12.0%, 3.0%;CMV-positive rates were 42.9%, 23.5%, 12.0%and 9.1%;PVB19 positive rate of 9.5%, 5.9%, 4.0%, 6.1%.Virus infection rate of DIHS group was obviously higher than other groups ( P<0.05 ) .There was no significant difference between severe drug eruption group, non-severe drug eruption group and healthy subjects ( P>0.05 ) .The seroprevalence of HHV ( HHV-6, HHV-7, EBV, CMV) in DIHS group and severe drug eruption group was signifi-cantly higher than non-severe drug eruption group and the control group ( P<0.05 ) .But there was no statistical difference in the seroprevalence of PVB19 among the four groups ( P>0.05 ) .In addition, multiple infection rates of DIHS group and severe drug eruption group were 38.1%, 27.5%, respectively, which significantly higher than the severe drug eruption group (9.3%) and control group (6.1%) .Conclusion:The onset of DIHS and severe drug eruption were correlated with the infection of HHV-6、HHV-7、EBV、CMV, but not PVB19.Therefore, HHV infection could be a trigger for the drug eruption getting worse.