Research on the Single Nucleotide Polymorphism of IL-23R in Psoriasis Patients from Han Ethnic Group
LUO Quan
ZHAO Tian
ZHANG Fang
LI Wei
LIN Ling
PAN Ning
GAO Xin-jing
ZHANG Xi-bao
Abstract：Objective:To investigate the relation between the genetic polymorphism of interleu-kin-23 receptor ( IL-23 R) and the psoriasis susceptibility in Han ethnic group .Methods:7 SNP locus of IL-23 R ( rs11209026、rs1004819、rs10489629、rs1343151、rs10889677、rs11209032、rs1495965 ) in NCBI database were searched .Ninety-three patients with psoriasis from outpatient and 108 healthy control were enrolled in this study .The relation of 7 SNP locus and psoriasis sus-ceptibility in 201 samples was analyzed .The data processing of polymorphism , logotype and psori-asis relative risks were all dealed with SPSS software .Results:The rate of 4 allelic genes among 7 TagSNP locus ( rs1004819、rs1343151、rs10889677、rs1495965 ) vary differently between the pa-tients group and the control group (P<0.01).Conclusion:IL-23R gene polymorphism is related to the psoriasis susceptibility .The SNP ( rs1004819、rs1343151、rs10889677、rs1495965 ) have a strong relation with the pathology of psoriasis .
Keywords：PsoriasisInterleukin-23RSingle nucleotide polymorphism
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 29-32 )