Expression Levels of Ang-1, Ang-2,Tie-2 and VEGF in Condyloma Acuminata Tissues
CHEN Wen-jing
SUN Xi-feng
WANG Xiao-hua
YU Huan-huan
PAN Hui-qing
LIN Er-yi
LIANG Chun-mei
LIU Han
CHEN Yong-feng
Abstract：Objective:To detect the expression levels of angiopointin 1(Ang-1), angiopo intin 2(Ang-2), Tie-2 receptor and vascular endothelial growth factor (VEGF) in condyloma acuminata tissues.Methods:The expression levels of Ang-1, Ang-2, Tie-2 receptorand VEGF in 30 condy-loma acuminata tissues and 20 normal tissues were detected by immunohistochemical technique . Results:The positive rates of Ang-2 , Tie-2 receptor and VEGF in condyloma acuminata tissues were 100%、93.33% and 100%, significantly higher than 25.00%, 40.00% and 45.00% in normal tissues (χ2=32.14,16.93,18.07 respectively,P<0.01).The positive rates of Ang-1 in condyloma acuminata tissues was 33.33%, and there was no statistical significance compared with normal tissues (χ2=0.06 , P >0.05 ) .Conclusion:Ang/Tie-2 signal transduction system and VEGF may play an important role on growth and recurrence in condyloma acuminate .
Keywords：Angiopointin-1Tie-2 receptorVascular endothelial growth factorCondyloma acuminate
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 6-9 )