Preliminary Study on the Correlation between Different Genotypes Chlamydia Trachomatis Infection and Clinical Manifestations in Women
YANG Bin
WANG Liu-yuan
XUE Yao-hua
HUANG Shu-jie
WEN Hai-quan
XIN Qin-song
ZHOU Fang
AI Jing
ZHENG He-ping
Abstract：Objective:To analyze the correlation between CT infection with different genotypes and clinical manifestations , and observe cHSP60 expression of cervical secretion in women with CT infection.Methods:VS1-VS2 sequence of major outer membrane protein was amplified by nes-ted PCR in the clinical specimens from 60 women with CT infection , followed by gene sequencing . Expression of cHSP 60 in cervical secretion was detected by ELISA .The correlation between infec-tion of different CT genotypes and clinical manifestations was analyzed .Results:Of 60 CT positive samples, serovars E, J, F, G, D and unidentified were present in 14 ( 23.33%), 14 (23.33%), 13 (21.67%), 9 (15%), 5 (8.33%), and 5 (8.33%) cases respectively.Ex-pression of cHSP60 increased significantly in J serovar compared with other serovars in cervical se-cretion (P<0.05).Expression of cHSP60 was higher in E genotype than that in G genotpye (P<0.05 ) .There was no correlation between different CT genotypes and clinical manifestations in women with genital CT infection ( P>0.05) .Conclusion:There could be no correlation between different CT genotypes and clinical manifestations in women with genital CT infection , but it de-serves to study on large sample size .
Keywords：Chlamydia trachomatisGenotypePathogenicityChlamydial heat shock protein 60 (cHSP60)
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 375-379 )