The Influence of Ferulic Acid Solutions on Proliferation of Melanocytes at Different Con-centrations
TANG Nan
WU Yan-hua
CAI Lan-hua
LI Qi-lin
Abstract：Objective:To investigate the impact of ferulic acid on proliferation of epidermal melanocytes in vitro.Methods:The normal epidermal melanocytes were identified by L-DOPA staining.After being treated with different concentrations (0.01,0.1,1 mg/mL) of ferulic acid for 24, 48, 72 h in vitro, the proliferative activity of cultured melanocytes were detected by MTS . Results:Compared with the control group without treatment with ferulic acid , the proliferation of the melanocytes were inhibited when treated with 0.01, 0.1, 1 mg/mL ferulic acid.The differ-ence were statistically significant ( P<0 .05 ) .Concentration and time have interaction .With the higher concentration and the prolonged of culture time , the inhibition of melanocyte proliferation was enhanced .Conclusion:Ferulic acid solution may inhibit the proliferation of normal human epi-dermal melanocytes .It suggests that ferulic acid may have potentials in the treatment of melasma and other pigmented disorders .
Keywords：Ferulic acidMelanocytesProliferation
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 372-374 )