Analysis on the Study on Cerebrospinal Fluids from 129 Cases of Untreated Early Syphilis
LI Min
XU Jing-xing
SHI Tong-xin
YU Zeng-zhao
ZHANG Cheng
LIU Shu-ping
Abstract：To investigate the significance of the cerebrospinal fluid detection for un-treated early syphilis and the diagnostic value for neurosyphilis.Methods:129 cases of cerebrospi-nal fluid ( CSF) in patients with untreated early syphilis were studied.Cell count, protein quanti-tative determination, VDRL, FTA -ABS, RPR, TPPA, and RT -PCR detection for TP were conducted.The abnormal conditions of cerebrospinal fluid in groups of different RPR titer and RT-PCR results were analyzed.Results:Abnormal cells or proteins were detected in cerebrospinal fluid of 30 cases (23.26%) , VDRL positive in 2 cases (1.55%) , FTA-ABS positive in 3 ca-ses (2.33%) , RPR positive in 5 cases (3.88%) , TPPA positive in 10 cases (7.75%) , RT-PCR for TP positive in 32 cases (24.81%) , among them, 2 cases (1.55%) were neurosyphilis. There was a statistical significance in frequency of CSF abnormality between patients with serum RPR titer≤1:16 and≥1:32 (χ2=8.37,P=0.004), as well as between the RT-PCR posi-tive for TP group and RT-PCR negative group (χ2=4.49,P=0.034) .Conclusion:Clinical at-tention should give to those patients with serum RPR titer≥1:32 and a higher frequency of CSF abnormality.TP detected by PCR in CSF is not particular helpful in for neurosyphilis diagnosis in patients with untreated early syphilis.
Keywords：Early syphilisCerebrospinal fluidDiagnosis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 185-188 )