Effects of Total Glucosides of Paeonia on PASI and Biochemical Markers of Atherosclerosis in Patients with Psoriasis Vulgaris
CAI Yi-xuan
LUO Miao-xuan
MI Xiang-bin
QIU Xian-wen
SUN Le-dong
ZHANG Tang-de
Abstract：Objective:To explore the response of total glucosides of paeonia on treatment of se-vere psoriasis vulgaris and effect on biochemical indicators of atherosclerosis .Methods:73 pait-ients with psoriasis vulgaris were randomly classified into two groups ,experimental group was com-posed of 38 cases being treated with oral total glucosides of paeonia combined with external calci -potriene, control group was composed of 35 cases whom only being treated with external alcipot-riene.The PASI score, hsCRP,LDL-C and HCY were evaluated at baseline and 4,8,12 weeks af-ter treatment .Results:The PASI score of two groups all presented downtrend within the first eight weeks , while only experimental group showed the trend of keep going down from 8 weeks on .After 12 weeks, the decline of the PASI score in experimental group was higher than that in the control group(x2 =4.98,P<0.05).Compared with the control group, the serum level of hsCRP, LDL-C and Hcy in experimental group were statistical significantly decreased ( P<0.05 ) .Conclusion:Total glucosides of paeonia can alleviate the severity of skin lesions of patients with posoriasis vul -garis and can also decrease the risk of atherosclerosis , which can induce the cardiovascular event .
Keywords：Psoriasis vulgarisTotalglucosides of paeoniaAtherosclerosis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 112-115 )