Transdermal Delivery of 8-Methoxypsoralen Nano-liposomes with Different Dosage-forms through Rat Skin in vitro
QIN Si
WEN Ju
ZHOU Gui-bin
ZHENG Rong-chang
Abstract：Objective:To explore the different transdermal effects of three dosage-forms of 8-methoxypsoralen ( 8-MOP ) flexible nano-liposomes including 8-MOP flexible nano liposome , 8-MOP nano-liposome gel and 8-MOP tincture .Methods:Three dosage forms of 8-MOP flexible nano-liposomes were put through the diffusing pool containing rat skin in vitro .The levels of 8-MOP in the rat skin as well as in the receiving pool were measured .The cumulative permeation quantity of three kinds of 8-MOP in different time points were recorded , and the content of 8-MOP in the rat skin of each two groups were compared by t-test.Results:Cumulative infiltration capacity in receiving pool of 8-MOP flexible nano-liposome gel group was obviously lower than that of 8-MOP flexible nano liposome group and 8-MOP tincture group , but the content of the 8-MOP in rat skin of 8-MOP nano-liposome gel groups was superior to that in the 8-MOP tincture group ( t=53.97, P<0.05), which in 8-MOP liposome group was significantly higher than that in 8-MOP liposome gel group (t=18.97, P<0.05).Conclusion:Three dosage forms of 8-MOP have dif-ferent characters , but the flexible nano-liposome form shows better skin affinity and is more condu-cive to drug retention in the skin .
Keywords：8-MethoxypsoralenNano-liposomesTransdermal
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 16-19 )