Infection Status and Gene Subtypes of Human Papilomavirus in Cervix

ZHANG Xing-ping; XIAO Ke-lin

doi:10.3969/j.issn.1674-8468.2014.01.003

Abstract：Objective:To investigate the infection and genotypes of human papilomavirus ( HPV) in cervix and provide experimental evidences for the epidemiological survey and prevention of HPV.Methods:DNA chip technology was used to detect 18 types of high risk and 5 types of low risk HPV in the cervical exfoliative cells collected by a cervix brush .Results:Among the 1 132 patients,265 cases (23.4%) were positive for the total 23 subtypes of HPV , in which 181 cases (15.9%) were high risk types,33 cases (2.9%)were low risk types and 81 cases(7.2%) infected with multiple genotypes .The most frequent types of high risk HPV were HPV 52(5.3%), HPV16(4.5%), HPV58(3.8%), HPV68(1.8%), HPV56 (1.7%) and HPV18(1.6%). The most frequent types of low risk were HPV 43 ( 3.7%) , HPV6 ( 1.9%) , HPV11 ( 1.8%) , HPV42(1.1%) and HPV44(0.1%).The predominant frequency of total HPV was observed in individuals between the age of 20 to 29(26.2%), and that of high risk types did between the age of 40 to 49(19.9%).However, the positive rate of HPV and high risk types HPV showed no sta-tistically significance among individuals on the ages of 20 -29,30 -39,40 -49 years(all P>0.05 ) .Conclusion:The high infection rate of HPV in females was observed .Infection with high risk types of HPV and multiple genotypes were common .HPV type 52 was protogene in the cer-vix.Gene subtypes of HPV was different in different regions .