Research advances on HER2 gene mutations in the treatment of malignant tumors
DUAN Xiaozhuo
WANG Yi
SONG Xiaowei
LYU Yanju
TIAN Dan
LI Li
Abstract：human epidermal growth factor receptor 2(HER2)gene mutations serve as critical drivers in various malignancies.Due to the diversity of mutation types,the functional changes in the HER2 protein vary significantly.Therefore,different targeted HER2 drugs need to be selected based on the specific mutation type.Current clinical practice and treatment strategies continue to be explored and optimized.This review comprehensively summarizes the diverse spectrum of HER2 gene mutations and evaluates corresponding clinical treatment strategies,aiming to provide insights for the development of personalized therapeutic approaches.
Keywords：human epidermal growth factor receptor 2gene mutationHER2 inhibitorsmalignant neoplasm
Publication Date：2026-02-28
Online Publishing Date：2026-04-01(First online date of this platform, not the publication date of the document)
Pages：7( 215-221 )