Research progress on chemokines and their receptors in colorectal cancer
XU Lei
SUN Pan
WANG Yao
YANG Juan
Abstract：This article aims to systematically elucidate the characteristics of the chemokine family,their mechanisms in the development and progression of colorectal cancer(CRC),clinical relevance,and diagnostic and therapeutic application value,as well as to explore the potential and current challenges of targeting chemokine pathways,in order to provide references for precision diagnosis and treatment of CRC and related research.By integrating research such as the classification and structure of chemokines,CRC-related molecular mechanisms,advances in diagnosis and treatment research,and targeting strategies(e.g,the CXCR4 inhibitor AMD3100),it has been found that chemokines and their receptors can regulate key processes in CRC,such as proliferation and metastasis,demonstrating potential as diagnostic biomarkers and therapeutic targets.Although strategies targeting chemokine pathways show promise for clinical application,existing challenges must be overcome to advance their translational application.
Keywords：colorectal cancerchemokineschemokine receptorstumor microenvironmenttargeted therapy
Publication Date：2026-02-28
Online Publishing Date：2026-04-01(First online date of this platform, not the publication date of the document)
Pages：5( 210-214 )