Clinical comparative study on different timing of transurethral resection of the prostate after transurethral resection of bladder tumor in patients with benign prostatic hyperplasia combined with bladder cancer
XIAO Bangming
YANG Erjiang
YAO Qisheng
LI Hao
WANG Li
CHEN Congbo
Abstract：Objective To investigate the clinical effects of transurethral resection of prostate(TURP)performed at different time points following transurethral resection of bladder tumor(TURBT)in patients with benign prostatic hyperplasia combined with bladder cancer.Methods A total of 92 patients with benign prostatic hyperplasia and bladder cancer who underwent TURBT between January 2021 and July 2023 were retrospectively analyzed.According to the timing of TURP,they were divided into a study group(TURP performed simultaneously with TURBT,n=46)and a control group(TURP performed 8 weeks after TURBT,n=46).Perioperative parameters,postoperative inflammatory and stress response indicators,and voiding function were compared between the two groups.The perioperative indicators,postoperative inflammation and stress response,and urinary function indexes of the two groups were compared,and the urinary symptom burden(BS)score and international Prostate Symptom Score(IPSS)were recorded.The incidence of postoperative complications and recurrence rate of bladder cancer at 24 months after surgery were followed up.Results The total operative time,intraoperative blood loss during TURP,hospitalization time,and catheter retention time in the study group were(68.15±22.51)min,(74.19±12.01)mL,(15.77±3.02)days,and(4.12±0.51)days,respectively,all of which were lower than those in the control group[(93.16±10.16)min,(109.53±17.43)mL,(28.16±5.66)days,and(6.22±1.56)days]with significant differences(t=6.868,11.302,13.099,8.678,P＜0.05).In contrast,there was no statistically significant difference in intraoperative blood loss during TURBT between the two groups(P＞0.05).On postoperative day 1,levels of interleukin-6,malondialdehyde,and lipid peroxides were higher in the study group(P＜0.05).One week after surgery,the maximum urinary flow rate in the study group was higher than that in the control group[(18.66±2.99)mL/s vs.(15.15±4.21)mL/s,t=4.610,P＜0.05],while the residual urine volume and intravesical pressure were lower than those in the control group[(33.87±7.15)mL vs.(42.08±9.55)mL,(13.31±3.02)cmH2O vs.(18.87±4.11)cmH2O,t=4.667,7.394,P＜0.05)].At 3 months after surgery,BS and IPSS scores were lower in the study group than in the control group(P＜0.05).The total incidence of postoperative complications was 17.39％in the study group and 13.04％in the control group,with no significant difference(P＞0.05).In the study group,5 cases(10.87％)of bladder cancer recurrence occurred within 24 months after surgery,and 4 cases(8.70％)in the control group,with no significant difference(P＞0.05).Conclusion In patients with with benign prostatic hyperplasia combined with bladder cancer,performing TURP simultaneously with TURBT shortens recovery and improves voiding,without significantly increasing 24-month recurrence risk,and is overall safe,though early postoperative inflammatory responses are more pronounced.
Keywords：bladder cancerbenign prostatic hyperplasiatransurethral resection of bladder tumortransurethral resection of prostateinflammatory responsestress responsetiming of surgery
Publication Date：2026-02-28
Online Publishing Date：2026-04-01(First online date of this platform, not the publication date of the document)
Pages：6( 204-209 )