Expression of NRG1,LGALS1 and UCHL1 in gastric cancer and their correlation with clinicopathological characteristics and prognosis
CHEN Zhuang
CHEN Runxiang
WANG Wenjun
Abstract：Objective To explore the relationship between neuregulin-1(NRG1),lectin galactoside-binding soluble 1(LGALS1),and ubiquitin carboxyl-terminal hydrolase L1(UCHL1)with their clinical pathological features and prognosis in gastric cancer tissue.Methods A total of 105 gastric cancer patients admitted to Hainan Cancer Hospital from January 2017 to January 2022 were selected.Immunohistochemical staining was used to detect the expression of NRG 1,LGALS1,and UCHL1 proteins in the cancer tissue and paired adjacent tissues during surgery.Patients were followed up for 3 years postoperatively,and their survival status were recorded.Kaplan-Meier method was used draw a survival curve,and Cox proportional hazards regression model was employed to analyze prognostic factors in gastric cancer patients.Results The positive expression rates of NRG1,LGALS1 and UCHL1 in gastric cancer tissues were 77.14％,74.29％and 68.57％,respectively,which were significantly higher than 20.00％,15.24％and 18.10％in adjacent tissues,and the differences were statistically significant(x2=68.627,74.032,54.473,all P＜0.05).The expression of NRG1,LGALS1 and UCHL1 showed statistically significant differences among patients with different TNM stages,histological differentiation degrees,lymph node metastasis status,and depths of invasion(all P＜0.05).Survival analysis revealed that the 3-year postoperative survival rates for patients with positive expression of NRG1,LGALS1,and UCHL1 significantly lower than patients with negative expression(58.02％vs.79.17％,57.69％vs.77.78％,56.94％vs.75.76％,x2=4.230,4.107,4.476,all P＜0.05).Multivariate Cox regression analysis indicated that positive expression of NRG1(HR=3.196,95％CI:1.302-7.843,P=0.011),LGALS1(HR=3.824,95％CI:1.449-10.090,P=0.007),UCHL1(HR=4.280,95％CI:1.459-12.553,P=0.008)in tissues,along with lymph node metastasis(HR=2.795,95％CI:1.234-6.329,P=0.014),were significant factors affecting the prognosis of gastric cancer patients.Conclusion NRG1,LGALS1,and UCHL1 are highly expressed in gastric cancer tissue and are closely related with the clinicopathological characteristics and prognosis of patients.
Keywords：gastric cancerneuregulin-1lectin galactoside-binding soluble 1ubiquitin carboxyl-terminal hydrolase L1clinical pathological featuresprognosis
Publication Date：2026-02-28
Online Publishing Date：2026-04-01(First online date of this platform, not the publication date of the document)
Pages：6( 155-160 )