Research progress on the ubiquitin-proteasome system influencing tumorigenesis through the regulation of cell cycle checkpoints
PU Jiawen
JI Chunya
MA Le
WANG Luyao
FU Ziyi
XU Pengfei
RUAN Hongjie
Abstract：Cell cycle checkpoints ensure the orderly progression of the cell cycle by precisely monitoring the fidelity of DNA replication and division.Their dynamic regulation is highly dependent on the spatiotemporally specific protein degradation mediated by the ubiquitin-proteasome system(UPS).Aberrant degradation of tumor suppressors or excessive accumulation of oncoproteins are key mechanisms driving uncontrolled cell proliferation,increased genomic instability,and ultimately tumorigenesis and cancer progression.This article systematically reviews the molecular mechanisms by which the UPS regulates cell cycle checkpoints through ubiquitination,examines its dysregulated patterns in the context of tumors,and summarizes the functional roles of E3 ubiquitin ligases and deubiquitinating enzymes in the regulation of cell cycle checkpoints.This review aims to provide a new theoretical basis for developing anticancer strategies targeting cell cycle regulation.
Keywords：TumorsCell cycle checkpointsUbiquitin-proteasome systemE3 ligaseDeubiquitinating enzymes
Publication Date：2025-10-28
Online Publishing Date：2025-12-03(First online date of this platform, not the publication date of the document)
Pages：7( 1025-1031 )