The expression and clinical significance of TRPA1 and TRPV1 in cervical cancer tissue
GOU Huiming
HOU Yu
YANG Chuan
NURMANQULI Rouzi
Abstract：Objective To investigate the expression of transient receptor potential anchor protein 1(TRPA1)and transient receptor potential vanillin 1(TRPV1)in cervical cancer tissues and their clinical significance.Methods A total of 90 patients with primary cervical cancer admitted to Guangyuan Central Hospital from January 2020 to December 2021 were selected,and cervical cancer tissues and corresponding adjacent tissue samples were collected.The expressions of TRPA1 and TRPV1 were detected by immunohistochemistry,and their relationships with the clinicopathological characteristics of patients were analyzed.The survival curve was plotted using the Kaplan-meier method,and the survival difference was tested by Log-rank.The Cox proportional hazards regression model was used to analyze the factors influencing the overall survival(OS)of cervical cancer.Results The high expression rate of TRPA1 in cervical cancer tissues was 69.2%(63/91),significantly higher than 33.0%(30/91)in adjacent tissues.The high expression rate of TRPV1 in cervical cancer tissues was 63.7%(58/91),which was also significantly higher than 29.7%(27/91)in adjacent tissues.High expression of TRPA1 was significantly correlated with the degree of differentiation(χ2=4.670,P=0.031),FIGO stage(χ2=6.742,P=0.009),depth of invasion(χ2=7.892,P=0.005),and distant metastasis(χ2=5.663,P=0.017).High expression of TRPV1 was significantly correlated with the degree of differentiation(χ2=8.987,P=0.003),FIGO stage(χ2=4.138,P=0.042),depth of invasion(χ2=4.701,P=0.036),and distant metastasis(χ2=5.968,P=0.015).Kaplan-Meier survival analysis showed that the median OS in the high-expression group of TRPA1 was 20 months,which was not reached in the low-expression group(P=0.001).The median OS in the high-expression group of TRPV1 was 17.5 months,which was not reached in the low-expression group(P=0.006).Univariate COX regression analysis indicated that TRPA1 was highly expressed(HR=2.081,95%CI:1.071-3.025),TRPV1 was highly expressed(HR=1.402,95%CI:1.113-2.558),and poorly differentiated(HR=1.661,95%CI:1.143-2.769),advanced FIGO stage(HR=1.538,95%CI:1.136-2.952),deep muscular layer infiltration(HR=1.368,95%CI:1.064-2.526),and presence of distant metastasis(HR=1.337,95%CI:1.203-2.436)are factors influencing the OS of patients with cervical cancer.Conclusion TRPA1 and TRPV1 are upregulated in cervical cancer tissues.Their high expression is closely related to adverse clinicopathological features and prognosis,and can be used as potential molecular markers for evaluating the prognosis of patients with cervical cancer.
Keywords：Cervical cancerTRPA1TRPV1Prognosis
Publication Date：2025-09-28
Online Publishing Date：2025-10-28(First online date of this platform, not the publication date of the document)
Pages：5( 874-878 )