Research progress on stress-induced mechanical cell competition in tumorigenesis and development
ZHANG Yan
WANG Yufeng
HAN Wei
Abstract：Cell competition is a pivotal quality control mechanism that plays essential roles in embryonic development,tissue homeostasis maintenance,and the progression of cancer.Recent investigations have shed light on the role of stress-induced cell competition,specifically mechanical cell competition,as a novel form of cellular competition that significantly impacts the promotion or suppression of tumor growth.Consequently,it assumes a critical function in both the genesis and advancement of cancer.This comprehensive review article aims to delve into the regulatory mechanisms governing stress-induced cell competition and elucidate its significance in the process of cellular elimination.Moreover,we will explore its potential as a promising target for therapeutic interventions in the context of cancer treatment.
Keywords：Cell competitionTumor progressionMechanical stressYes-associated protein/transcriptional co-activator PDZ-binding motif
Publication Date：2025-08-28
Online Publishing Date：2025-10-21(First online date of this platform, not the publication date of the document)
Pages：5( 810-814 )