Progression of CHIP/STUB1 in tumors
GU Yujie
ZHU Haonan
SHU Yongqian
Abstract：C-terminal Hsp70-interacting protein(CHIP),also known as STIP1 homology and U-box containing protein 1(STUB1),is an important E3 ubiquitin ligase.It plays multiple roles in the occurrence,development,and metastasis of various cancers.It maintains protein homeostasis by degrading misfolded proteins,and it forms complexes with heat shock proteins Hsp70 and Hsp90,thereby influencing cell survival and stress responses.Research shows that CHIP has a dual role in cancer:On one hand,it acts as a tumor suppressor by inhibiting cancer stem cell properties.It promotes the degradation of suppressor factors,exerting anti-cancer effects.On the other hand,in some cases,CHIP may promote tumor growth and metastasis.The expression and activity of CHIP are regulated by several signaling pathways.These include AKT,MAPK,and NF-κB.These pathways are important in tumor proliferation and metastasis.Additionally,epigenetic regulation significantly affects CHIP's function.As we learn more about CHIP,studies are exploring its potential as a therapeutic target.This article systematically reviews the functions and multiple roles of CHIP in tumors,aiming to provide new insights and directions for further exploration of its application in early diagnosis and treatment of cancer.
Keywords：TumorCHIPSTUB1Tumor progressionTherapeutic target
Publication Date：2025-08-28
Online Publishing Date：2025-10-21(First online date of this platform, not the publication date of the document)
Pages：7( 803-809 )