Research progress of vascular adhesion protein-1 in thyroid cancer
HE Yaxin
YAN Yanfang
HU Zhigang
Abstract：Vascular adhesion protein-1(VAP-1)is a unique endothelial cell adhesion molecule and aminourea-sensitive amine oxidase that plays an important role in inflammation and various diseases.Recent studies have shown that VAP-1 is closely related to the occurrence,development,and prognosis of thyroid cancer.This article summarizes the basic characteristics,physiological functions,and expression of VAP-1 in thyroid cancer tissues through literature review,and explores the mechanisms by which VAP-1 promotes the proliferation,migration,invasion,and microenvironment regulation of thyroid cancer.It also analyzes the potential of VAP-1 as a diagnostic marker and therapeutic target for thyroid cancer.The development and application prospects of VAP-1 inhibitors are discussed,as well as the future research direction and challenges,in order to provide new ideas and methods for the diagnosis and treatment of thyroid cancer.
Keywords：Thyroid cancerVascular adhesion protein-1Diagnostic markersTherapeutic target
Publication Date：2025-05-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 512-517 )