Research progress of NK cell therapy in brain glioma immunotherapy
CHEN Yongqiong
ZUO Anxiu
SU Mouxiao
Abstract：Objective Glioma is one of the highly malignant brain tumors.Although traditional methods such as surgery,adiotherapy/chemotherapy can prolong the survival of patients,the curative effect is still limited.In recent years,with the rapid development of immunotherapy,especially the application of natural killer(NK)therapy in the treatment of glioma,it provides a new solution for the treatment of glioma.NK cells are innate immune cells with the ability to directly kill tumor cells and are potential target cells for glioma immunotherapy.Therefore,this article reviews the research progress of NK cell therapy in brain glioma immunotherapy,including the basic characteristics of NK cells,anti-tumor mechanism,the immunomodulatory role of NK cells in brain glioma,and the application of NK cell therapy in brain glioma.
Keywords：GlioblastomaNatural killer cellsImmunotherapyTransfusion
Publication Date：2025-03-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 302-306 )