Clinical observation of the relationship between poorly differentiated cell population and occult liver metastasis after colorectal cancer surgery
ZHANG Xuejun
LI Nanyang
WANG Feng
WANG Jie
Abstract：Objective To investigate the relationship between poorly differentiated cell populations(PDCs)in colorectal cancer and the occurrence of occult liver metastasis in patients after radical surgery.Methods The clinical medical records of 185 patients who received radical resection of colorectal cancer in Zhangjiakou First Hospital from July 2020 to July 2022 were retrospectively analyzed.The PDCs grade was detected by pathological HE staining,and the relationship between PDCs grade and clinicopathological features was analyzed.After 12 to 36 months of postoperative follow-up,patients were divided into metastatic group(n=46)and non-metastatic group(n=139)according to whether occult liver metastasis occurred.The clinical data of the two groups were compared,and the risk factors of occult liver metastasis after colorectal cancer surgery were analyzed by Logistic regression model.Results PDCs grade in colorectal cancer tissues was not correlated with gender,age,tumor diameter,tumor location,abdominal fluid and intestinal perforation(P>0.05),while PDCs grade was correlated with peripheral nerve invasion,lymph node metastasis,differentiation degree,vascular invasion and pathological T stage(P<0.05).The proportion of patients with tumor diameter≥5 cm,peripheral nerve invasion,lymph node metastasis,low differentiation,vascular invasion,stage T3-4 and PDCs grade G3 in metastatic group was higher than that in non-metastatic group,with statistical significance(P<0.05).The results of multivariate Logistic regression model showed that lymph node metastasis,vascular invasion,peripheral nerve invasion and PDCs grade were the risk factors for occulting liver metastasis in patients(P<0.05).Conclusion The grade of PDCs in colorectal cancer tissues is related to peripheral nerve invasion,lymph node metastasis,differentiation degree,vascular invasion and pathological T stage,and lymph node metastasis,vascular invasion,peripheral nerve invasion and PDCs grade G3 are risk factors for occult liver metastasis in colorectal cancer patients.
Keywords：Colorectal cancerPoorly differentiated cell populations(PDCs)Occult liver metastasis
Publication Date：2025-03-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 215-219 )