Hepatobiliary Small Cell Neuroendocrine Carcinoma: A Rare Case Report
Abstract：Neuroendocrine tumors (NETs) are heterogeneous tumors originating from enterochromaffin cells, and they are a rare type of tumor. The incidence rate is approximately 5.25 per 100,000 people. Neuroendocrine carcinoma (NEC) of the gallbladder, as a poorly differentiated NET, is even rarer [1]. Only 0.2% to 0.3% of NETs originate from the bile ducts, and most extrahepatic cholangiocarcinomas are adenocarcinomas (NEC) [2]. NETs are classified into NET grade 1 (G1), NET grade 2 (G2), and neuroendocrine carcinoma [3]. Primary hepatic neuroendocrine neoplasms (PHNEN) are also a rare type of tumor, accounting for 0.3% of neuroendocrine tumors and 0.28% to 0.46% of liver malignancies [6]. Herein, we report the diagnostic and treatment situations of three female patients with hepatobiliary neuroendocrine carcinoma based on pathological and immunohistochemical findings. This study has been approved by the Ethics Committee of the Affiliated Drum Tower Hospital, Medical School of Nanjing University (Approval No.: 2024-531-01).
Keywords：Hepatobiliary small cell neuroendocrine carcinomaImmunotherapyPathologyImmunohistochemistry
Publication Date：2025-02-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 202-205 )