Clinicopathological features and prognosis of 175 patients with multiple primary malignant tumors
TONG Mengting
ZHOU Xun
ZENG Fanye
LOU Fang
LI Da
ZHANG Hongliang
Abstract：Objective To retrospectively analyze the clinical and pathological characteristics and prognosis of patients with multiple primary cancers(MPMTs).Methods A retrospective analysis was conducted on the clinical data of patients with MPMTs from 2009 to 2019.The general information,treatment status,genetic profile and prognosis were analyzed.Results A toal of 175 cases(1.2%)of MPMTs were screened from 15 268 cancer patients.Among them,there were 76 males and 99 females.The median ages when the first,second,and third primary cancer diagnosed were 54.9 years,63.5 years,and 59.4 years,respectively.There were 164 cases of Han ethnicity and 11 cases of ethnic minorities.Among the 175 cases,there were 48 cases(27.4%)of synchronous multiple primary cancers(SMPMTs)and 127 cases(72.6%)of metachronous multiple primary cancers(MMPMTs).The third primary cancer occurred in nine cases(5.1%).The distribution of tumors included digestive tract,urinary system,reproductive system,lung,breast,and head and neck.Digestive tract tumors were the most common primary tumors,followed by breast tumors.Thirteen patients with MPMTs underwent genetic testing,and a total of 11 specific gene mutations were detected.The treatment methods included surgery,radiotherapy,chemotherapy,endocrine therapy,targeted therapy,immunotherapy,interventional therapy,best supportive therapy and traditional Chinese medicine.The median overall survival(OS)for the entire group was 72.0 months.The median OS of 11 ethnic minority patients was 72.0 months.The median OS of MMPMTs and SMPMTs patients were 72.0 months and 72.0 months,respectively(P=0.23).Conclusion Most MPMTs patients are middle-aged and elderly,and the primary tumors are mostly gastrointestinal and breast tumors.There is no significant difference in the OS among MPMTs patients of different ethnic groups in Xinjiang.
Keywords：Multiple primary malignant tumorsMulti-ethnic settlementsClinicopathological characteristicsPrognosis
Publication Date：2025-01-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 27-31 )