Research progress on angiogenesis in osteosarcoma
HAN Zhongwei
REN Ke
Abstract：Osteosarcoma is common in adolescents,with difficulty in early diagnosis,high risk of metastasis,and poor prognosis.The process of angiogenesis provides nutrients for the growth and invasion of osteosarcoma and promotes distant metastasis,significantly affecting its malignant potential.The development of anti-angiogenic drugs targeting various aspects of the angiogenesis process has been a hot topic in recent years.However,the angiogenesis process is complex and regulated by numerous factors,and osteosarcoma tissues are prone to developing resistance to targeted drugs.Therefore,the current anti-angiogenic efficacy of osteosarcoma is still not ideal.This article reviews the hot regulatory factors related to angiogenesis in osteosarcoma in recent years,aiming to provide a reference for the selection of anti-angiogenic drug targets and clinical diagnosis and treatment.
Keywords：OsteosarcomaTmor angiogenesisAnti-angiogenic therapyVascular endothelial growth factorTumor microenvironment
Publication Date：2024-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1241-1246 )