Expression level of recinoid X receptor B in endometrial carcinoma tissues and its clinical significance
HUANG Haixia
ZHOU Yahong
SUN Yuanlu
SUN Ling
WANG Beibei
Abstract：Objective To investigate the expression and clinical significance of retinoid X receptor B(RXRB)in endometrial carcinoma tissues.Methods Expression of RXRB gene in endometrial cancer tissue was analyzed using the Cancer Genome Atlas database.Expression level of RXRB in endometrial tissues were detected byusing immunohistochemistry and real-time fluorescence quantitative polymerase chain reaction(qPCR).Relationship between RXRB expression and clinical pathological characteristics of endometrial cancer patients as well as its impact on prognosis were further investigated.Results Online analysis results showed that the median(quartile)level of RXRB in 546 cancer tissues was 28.460(22.671-34.955),lower than 43.747(41.999-48.291)in 35 normal tissues and the difference was statistically significant(P＜0.001).Immunohistochemical and qPCR results showed that the integrated optical density value,positive rate and mRNA level of RXRB were 1.692±0.143,66.67％(30/45)and 0.519±0.249 in endometrial cancer tissues,all lower than 5.263±1.038,86.67％(39/45)and 1.000±0.461 in normal endometrial tissue(P＜0.05).RXRB expression was associated with lymph node metastasis,tumor staging,and differentiation degree(P＜0.05).Univariate analysis revealed that the median overall survival of individuals with positive RXRB expression was unreached,better than 18.0 months of those with negative expression(HR=9.901,95％CI:2.603-31.762,P＜0.001).Further multivariate analysis showed that negative expression of RXRB was an independent risk factor for poor prognosis in endometrial cancer patients(HR=6.497,95％CI:2.891-14.601,P=0.021).Conclusion Low expression of RXRB is associated with the occurrence and development of endometrial carcinoma,which often indicates poor prognosis.This gene is expected to become a potential intervention target for endometrial cancer.
Keywords：Endometrial cancerRetinoid X receptor BClinical significancPrognosis
Publication Date：2024-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1232-1236 )