Predictive values of systemic immune inflammatory index and the ratio of C-reactive protein to albumin for urinary tract infection risk after bladder cancer surgery

LIU Huaying; LEI Yulian; YANG Tianli; QIN Zhiqiang; XU Ning

doi:10.3969/j.issn.1009-0460.2024.12.011

Abstract：Objective To explore the expression characteristics of systemic immune inflammatory index(SⅡ)and the ratio of C-reactive protein(CRP)to albumin(ALB)in patients with bladder cancer,and build a risk prediction system of urinary tract infection after transurethral resection of bladder cancer and analyze its clinical value.Methods From January 2020 to June 2022,120 patients with bladder cancer who received transurethral resection of bladder tumor were selected as the study subjects.They were divided into postoperative urinary tract infection group(n=57)and uninfected group(n=63)according to the diagnostic criteria for urinary tract infections.Clinical data of bladder cancer patients were collected and Logistic regression model was used to analyze the risk factors of postoperative urinary tract infection in bladder cancer patients.The predictive value of SⅡ,CRP/ALB system on urinary tract infection after bladder cancer surgery was analyzed by receiver operating characteristic curve.Pearson correlation analysis was used to investigate the correlation between SⅡ,CRP/ALB systems and bladder tumor-associated antigen(BTAA).Kaplan-Meier survival curve was used to analyze SⅡ,CRP/ALB system and survival of bladder cancer patients.Results The levels of SⅡ and CRP/ALB in the urinary tract infection group after transurethral bladder tumor resection were higher than those in the non-infection group(t=2.117,2.372,P＜0.05).Age＞60 years old,positive preoperative urine culture,high SⅡ and CRP/ALB values were independent risk factors for urinary tract infections after transurethral bladder tumor resection.The area under the evaluation curve of SⅡ and CRP/ALB for urinary tract infection after bladder cancer surgery was 0.804 with the sensitivity of 82.46％and specificity of 80.95％,respectively.The levels of SⅡ and CRP/ALB were positively correlated with BTAA(r=0.643,0.395,P＜0.001).The levels of SⅡ and CRP/ALB increased,and the patient survival rate decreased(x2=18.601,24.515,P＜0.001).Conclusion SⅡand CRP/ALB systems are valuable biomarkers for the evaluation of urinary tract infection after transurethral resection of bladder cancer,and can provide reference for clinicians to formulate strategies for the prevention and treatment of urinary tract infection after bladder cancer surgery.