Prognostic value of B and T lymphocyte attenuator in triple-negative breast cancer
ZHU Xiaocun
ZHEN Linlin
LI Zhi
SONG Wei
WAN Jiangyang
ZHAO Ruipeng
Abstract：Objective To analyze the biological function of B and T lymphocyte attenuator(BTLA)and their prognostic prediction in triple-negative breast cancer(TNBC)patients.Methods One hundred and forty female patients with TNBC who underwent surgery were selected.The expression of BTLA protein and mRNA in cancer and adjacent tissues of TNBC patients were detected.The prognosis of patients with different BTLA expression was analyzed in Kaplan-Meier plotter database.Cox regression was used to analyze the influence of clinicopathological characteristics and BTLA expression on the prognosis of TNBC patients.According to the Cox regression results,a nomogram prediction model was made with R language and evaluated.Results The expression level of BTLA in adjacent tissues was higher than that in cancer tissues(P＜0.01).There were 69 patients with positive expression and 71 patients with negative expression of BTLA,and the proportions of high serum carbohydrate antigen 50,high tumor grade,advanced pT stage and pN stage in the BTLA-positive group were lower than those in the BTLA-negative group(P＜0.05).Analysis conducted on the Kaplan-Meier plotter database showed that TNBC patients with high BTLA expression had a better prognosis(P＜0.05).Multivariate Cox regression analysis showed that TNBC patients with higher pathological grade,advanced pT and pN stages,and negative BTLA expression had poorer prognosis(P＜0.05).According to the nomogram model established by significant parameters in the Cox multivariate analysis,the model C index was 0.763(95％CI:0.724-0.829).Conclusion The expression level of BTLA is lower in cancer tissues compared to adjacent tissues in TNBC patients.BTLA expression is an independent factor for predicting disease-free survival in TNBC patients.The nomogram established in this study has good clinical application and predictive value.
Keywords：Triple-negative breast cancerB and T lymphocyte attenuatorSurvival prognosisCox regression analysisNomogram
Publication Date：2024-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1194-1199 )